小児期における間脳-下垂体-副腎皮質系のfeedback機構に関する研究
スポンサーリンク
概要
- 論文の詳細を見る
Responses of the hypothalamic-pituitary-adrenal axis to the administration of glucocorticoids were investigated in infants and children, particularly with respect to development of those responses. The group of subjects consisted of 57 individuals. One portion contained 36 persons ranging in age from three months to 15 years who had no endocrine or central nervous system disorders. Six adults in good health comprised another portion. These subjects were separated into the following four groups : infants of three months to one year; younger children of one to six years; older children of seven to 15 years; and adults or those 20 to 30 years old. Finally, 15 patients with congenital adrenal hyperplasia, primordial dwarfism, central nervous system disorders or anorexia nervosa were studied.<BR>Serum cortisol levels were determined from blood samples taken at 9 a.m. for 3 consecutive days both before and after the intramuscular injection of dexamethasone at 11 p.m. The method of measurement followed the competitive protein-binding technique of Murphy. For purposes of comparison, the measured serum cortisol levels were transformed into suppression rates from results obtained before and after the administration of dexamethasone.<BR>No significant differences of suppression rates were found among these four age groups when dexamethasone was given according to body surface area (0.25 mg/m<SUP>2</SUP>). It was noted in infants that with increasing doses of dexamethasone (0.06 mg -0.50 mg/ m<SUP>2</SUP>), the suppression rates likewise increased. Suppression rates of subjects with anorexia nervosa, however, were abnormally low. These results indicate that infants and children have a negative feedback mechanism operating on the hypothalamic-pituitary-adrenal axis of approximately the same level observed in adults. Negative feedback mechanism may be affected in some diseases, for example anorexia nervosa.
- 一般社団法人 日本内分泌学会の論文