新生児期のGH, TSH, LH, FSH分泌動態に関する研究:第一編生理的状態下におけるGH, TSH, LH, FSHの変動
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概要
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Eighty-two normal full-term neonates who had no abnormalities at gestation or at birth, and 32 of their mothers were selected to measure GH, TSH, LH, FSH, T<SUB>3</SUB>, HCG, HPL, IRI, Glucose and NEFA in the umbilical arterial and venous blood, neonatal blood and maternal blood. Hormones were measured by radioimmunoassay. The following results were obtained.<BR>1) GH levels were significantly higher in the umbilical blood than in the maternal blood (P<0.01) but were almost the same between the umbilical arterial and venous blood.<BR>2) GH levels reached a peak 24 hours after birth in the group A infants in which feeding started 12 hours after birth, and reached a peak 48 hours after birth in the group B infants in which feeding started 24 hours after birth. GH levels which were measured at 72 and 96 hours after birth were significantly higher in the group B infants than in the group A (PC 0.01).<BR>3) Differences of GH secretory patterns between groups A and B, depending on the time of initial feeding, were strongly related to those changes in NEFA and glucose levels between both groups at birth. The secretion of GH was inhibited by the increase of NEFA and was stimulated by the decrease of NEFA and the increase of glucose.<BR>4) TSH levels were significantly higher in the umbilical blood than in the maternal blood (P<0.001). T<SUB>3</SUB> levels were significantly lower in the umbilical blood than in the maternal blood (P<0.01).<BR>5) TSH levels increased rapidly with a peak immediately after birth and then showed a decreasing tendency, but they remained significantly higher during the first 24 hours than they did thereafter. T<SUB>3</SUB> levels remained at a low level during the first 12 hours and then showed a rapid increase with a peak 24 hours after birth.<BR>6) There were no differences in LH-HCG levels in the umbilical blood between male and female infants. In the early neonatal period, LH levels were higher in the males than in the females and were statistically higher in the males 96 and 168 hours after birth (P<0.01).<BR>7) FSH levels in the maternal blood, umbilical blood and neonatal blood during 96 hours after birth remained less than 2.0 mIU/ml. There were no differences in FSH levels between male and female infants.<BR>8) About 1/300 of the amounts of HCG and HPL in the maternal blood was observed in the umbilical venous blood. The amounts of HCG and HPL in the umbilical arterial blood were about half of those in the umbilical venous blood. HCG and HPL levels were undetectable in the blood of almost all the infants during the first 24 hours after birth.<BR>9) The effects of HCG and HPL on the measurement of GH and TSH by radioimmunoassay seemed to be negligible. Although LH measurement in the umbilical blood appeared to be influenced by HCG, it could be almost free from the influence of HCG 12 hours after birth.<BR>10) Change in IRI was not related to that in GH in the early neonatal period.
- 日本内分泌学会の論文