IUD挿入家兎子宮内膜のprostaglandins濃度:-子宮内膜prostaglandinsに及ぼす性steroidの影響-

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概要

• 論文の詳細を見る

• Intrauterine devices (IUD) have become popular in recent years. However, their mode of action is still poorly understood. Several studies have demonstrated an increase in prostaglandins in uterine horns bearing IUDs in rats, sheep and hamsters. As one hypothesis, increased synthesis of prostaglandins within the uterine cavity was proposed. In the present investigation, the changes of prostaglandin (PGE<SUB>1</SUB> and PGF<SUB>2α</SUB>) content in rabbit endometrium bearing IUDs were studied by injecting hCG intravenously and measuring serum unconjugated estradiol and progesterone before and after ovulation.<BR>As an intrauterine device, silk No. 7 suture was inserted transabdominally into a single uterine horn of mature female rabbits 1 to 2 months before examination (the IUD-bearing group). The rabbits of the control group did not receive any surgical treatment (the untreated group). Endometrial tissue and blood samples were obtained at designated times before and after hCG administration. All the compounds were measured by radioimmunoassay.<BR>1) In the untreated group, the PGE<SUB>1</SUB> content in the endometrium was raised 12 hours (P<0.05) and 5 days (P<0.01) after the administration of i.v. 100 IU hCG, while no increase in endometrial PGF<SUB>2α</SUB> was found throughout the 5 days after the hCG administration.<BR>2) In the IUD-bearing group, PGE<SUB>1</SUB> content in the IUD inserted horn was higher than in the contralateral horn before (P<0.01), and 12, 48 and 72 hours (P<0.05, each) after the hCG administration. On the other hand, PGF<SUB>2α</SUB> content in the IUD inserted horn was higher than in the contralateral horn before and 12 hours after the hCG administration (P<0.05, each) and then decreased to the levels of the contralateral horn or the horn of the untreated group.<BR>3) The levels of endometrial PGE<SUB>1</SUB> of both groups changed in parallel with the levels of serum estradiol, while the levels of endometrial PGF<SUB>2α</SUB> showed a negative correlation to the levels of serum progesterone.<BR>4) There were no significant differences between the serum estradiol and progesterone levels in the IUD-bearing group and the untreated group before and after the hCG administration.<BR>These results suggest that the increasing period of endometrial prostaglandins in the IUD-inserted horn give results similar to the most effective timing of prostaglandin administration for contraception.

• 日本内分泌学会の論文

著者

• 徳永 達也

  熊本大学医学部産科婦人科学教室

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• IUD挿入家兎子宮内膜のprostaglandins濃度:-子宮内膜prostaglandinsに及ぼす性steroidの影響-

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