膵広範切除後の糖代謝と残存膵内分泌機能の変化特にSandmeyer型糖尿病における抗インスリン系機能の変動について
スポンサーリンク
概要
- 論文の詳細を見る
Changes in glucose tolerance and the function of the anti-insulin system after a major resection of the canine pancreas were divided into three types.<BR>Immediately after the removal of 90 per cent or more of the pancreas, diabetes developed, and the function of the anti-insulin system was depressed, showing a poor response of glucagon secretion to hypoglycemia after insulin load and degeneration or destruction of the islet cells and both A and B cells, and the dosage of insulin required to control blood sugar was close to that of a total pancreatectomy.<BR>6 to 24 weeks after the removal of 70 to 90 per cent of the pancreas, so-called Sandmeyer's diabetes occurred, in which glucose tolerance and the function of the anti-insulin system were within the normal range during the early postoperative periods, but the function of the anti-insulin system was highly activated later, showing a high response of pancreatic glucagon secretion to hypoglycemia after insulin load, accompanied by degeneration of B cells, but not A cells. These results could well explain the fact that the insulin dosage needed to control blood sugar in Sandmeyer's diabetes was 3 to 4 times more than it was in total pancreatectomy.<BR>After the removal of 70 per cent or less of the pancreas, diabetes did not occur, and glucose tolerance and the function of the anti-insulin system were maintained well, without any significant change in the islets of the remnant pancreas.<BR>Insulin therapy relieved the disturbed function of the anti-insulin system in diabetes following pancreatectomy.
- 日本内分泌学会の論文