甲状腺ヨウ素濃度のIn Vivo螢光X線分析による測定とその臨床的有用性の研究

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With the purpose of evaluating the clinical usefulness of measuring thyroidal iodine concentrations and contents, a simple apparatus was designed and constructed for in vivo x-ray fluorescent analysis. The apparatus consists of an Am-241 exciting source (300mCi) and pure Ge detector (50mm2 × 5mm) for measuring Kα fluorescent x-rays (28.3 and 28.6 KeV) emitted from exited iodine. A diversing collimator was so designed that most of one lobe of the thyroid is within the field of view. Counting was usually continued for 4-5 minutes on each lobe to obtain the sensitivity of 0.2mg/g allowing 30% coefficient of variation. Iodine concentrations measured in 34 resected normal thyroids at autopsy ranged from 0.19-1.34mg/g with a mean of 0.53mg/g (male 0.48 ± 0.19mg/g, female 0.60 ± 0.32mg/g _??_±1.s.d.). The results correlated well with the measurement of the same thyroids by activation analysis (r=0.93).In vivo measurement was performed on healthy volunteers including 16 males and 14 females. Iodine concentrations measured on each lobe of the thyroid revealed 0.40 ± 0.24 mg/g for males and 0.67 ± 0.29 mg/g for females. Eighty-four measurements were performed on 80 patients with various thyroidal diseases. Iodine concentrations were low in chronic thyroiditis (0.06 0.13mg/g) and subacute thyroiditis (0.28 ± 0.12mg/g). Most patients with Graves' disease showed normal or low iodine concentrations (0.47 ± 0.29mg/g) regardless of status of treatments (pre-, under-or posttreatment) or thyroidal function. Twenty-one measurements were performed on 21 patients with nodular goiter. Nodule/Gland ratio of I-127 concentration was 0.78 ± 0.47 in 17 patients with cold nodule, and it ranged from 1.2-1.9 in 4 patients with hot nodule.
日本内分泌学会の論文

甲状腺ヨウ素濃度のIn Vivo螢光X線分析による測定とその臨床的有用性の研究

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