ヒト前立腺組織内Androgen濃度について

概要

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Endogenous androgen levels of prostatic tissues in patients with benign prostatic hypertrophy (BPH) and untreated prostatic cancer (PC) were determined by radioimmunoassay using sephadex LH-20 column chromatography. By this assay procedure, it was possible to measure tissue androgen levels with only 30-40 mg weight of tissues.<BR>In BPH (n=20) the concentrations of steroids (mean ± standard deviation, ng/g. tissue weight) were 5α-androstane 3α, 17β diol (A-diol), 2.31 ± 1.29; dihydrotestosterone (DHT), 4.97 ±2.17; testosterone (T), 0.62 ± 0.33. In PC (n=17) the concentrations were 5.51 ± 3.23; 3.94 ± 3.16; and 0.93 ± 0.38; respectively. The concentrations of DHT were raised and the levels of A-diol were reduced significantly (P<0.01) in BPH compared with PC. Tissue DHT levels of PC were variable, but they could be classified in to two groups. One was below 2 ng levels (n=8) similar to those of non-androgen target tissues and the other was over 2 ng (n=19). The relationships between histological differentiation and tissue DHT levels in prosatic cancer were examined. In poorly differentiated cancer (n=4), DHT levels were low in all cases, furthermore even in well differentiated ones there were 4 cases with levels below 2 ng. Thus, the measurement of endogenous DHT levels of prostatic tissues was considered to be valuable for the judgement of androgen dependency in prostatic cancer.
日本内分泌学会の論文