卵巣除去後progesterone処置したラットにおけるandrogenの妊娠維持効果

概要

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Pregnant rats ovariectomized on day 14 of pregnancy (Sperm present = day 1) were daily treated with 4 mg progesterone (P) plus androgens, and the effects of the androgens on fetal survival and intrauterine pressure were examined on day 20 of pregnancy. In the rats treated with P only, the percentage of live normal fetuses was only 40.4% of the total fetuses, 39.4% were injured fetuses having hematomata on their extremities, and 20.2% were absorbing. Intrauterine pressure was about three times higher than that in the sham-operated controls. Treatment with androgen as well significantly increased the percentage of live normal fetuses and decreased intrauterine pressure, as estrogen did. A significant negative correlation was observed between the percentage of live normal fetuses and intra-uterine pressure. Androstendiol (A-diol) was most effective and its daily dose of 2 pM maintained normal pregnancy. A-diol and dehydroepiandrosterone (DHA) were more effective than androstendione (A-dione) and testosterone (T), suggesting that the effect of the former two androgens is not by conversion to estrogen, but by their direct action on the uterine wall. 5α-dihydrotestosterone, a non-aromatizable androgen, also exhibited moderate estrogenic action.
一般社団法人日本内分泌学会の論文