実験的甲状腺機能異常ラットにおける血漿, 心房及び視床下部心房性Na利尿ペプチド(ANP)の変動について

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概要

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• In order to assess a possible involvement of thyroid hormone in atrial natriuretic peptide (ANP), experimentally induced hyper- and hypothyroid rats were employed, and the immunoreactive rat ANP (IR-ANP) concentrations in plasma, atria and brain regions including the hypothalamus were measured by a specific radioimmunoassay. Plasma IR-ANP concentration in hypothyroid rats was 14.5±2.9 (mean ± SEM) fmol/ml, significantly lower than that in control rats (p<0.05 vs control of 24.9±9.7 fmol/ml). Plasma IR-ANP concentration in hyperthyroid rats was 66.4±9.7 fmol/min, significantly higher than that in the controls (p<0.01). Atrial IR-ANP concentration in hyperthyroid rats was significantly lower than that in the controls (79.9±11.1 nmol/g vs 133.5±21.2 nmol/g (control), p<0.05), though no significant change was observed in atrial IR-ANP concentration in hypothyroid rats.<BR>While hypothalamic ANP concentration in hypothyroid rats was significantly lower than that in the controls (17.5±3.5 pmol/g vs 31.9±1.9 pmol/g (control), p<0.05), there was no significant change of that in the hyperthyroid rats. On reverse phase high performance liquid chromatography, the major peak in plasma and hypothalamus extract was thought to be identical to synthetic α-rat ANP (1-28). These results may suggest that in the hyperthyroid state an excessive amount of ANP is released from atria into the blood, and that in the central nervous system thyroid hormone involve ANP metabolism being different from the atrium.

• 一般社団法人 日本内分泌学会の論文

著者

• 鈴木 義信

  獨協医大・内分泌内科

• 小堀 博文

  獨協医大・内分泌内科

• 橋上 好久

  獨協医大・内分泌内科

• 堀越 健太郎

  獨協医大・内分泌内科

• 下田 新一

  獨協医大・内分泌内科

• 鈴木 仁

  獨協医大・内分泌内科

• 村松 弘章

  獨協医大・内分泌内科

• 大武 龍介

  獨協医大・内分泌内科

• 土屋 時彦

  獨協医大・内分泌内科

関連論文

• 実験的甲状腺機能異常ラットにおける血漿, 心房及び視床下部心房性Na利尿ペプチド(ANP)の変動について

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