腎癌患者の免疫能に対するIFN-αの影響

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The changes in the subsets of peripheral blood lymphocytes before and after IFN-αadministration for renal cancer patients was studied. NK cytotoxicity and 2-5AS were also examined. We found no change in all the subsets of lymphocytes, NK cytotoxicity and 2-5AS during the day at control period. CD16+CD57-decreased significantly three hours after first administration of IFN-α(P<0.05). CD16+CD57-, CD16+CD57+, CD16+CD56+, CD3+HLADR+, CD4+CD8+ increased significantly after 1 week administration. CD4+CD8-decreased significantly after administration. 2-5AS had a tendency of increase after administration. The results suggest that IFN-αadministration activates NK cells and T lymphocytes.
Kinki Brain Tumor Pathology Conferenceの論文