眼科用メチルセルロース誘導体水溶液のゲル化 I
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概要
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Hydroxypropylmethylcellulose (HPMC) saline solution at the weight concentration of ca. 2% is one of media used as space filler for an anterior chamber in the recent ophthalmic viscosurgery of cataract extraction and intraocular lens implantation. As there are many insoluble particles in crude solutions of HPMC, we should filtrate the solution for medical use. Viscosity 77 and optical absorbance A<SUB>540</SUB> of a filtrated HPMC solution were measured with the concentration of 1% at the heating and cooling rates θ=0.25 0.40 and 0.70°C /min. Remarkable hysteresis curves were observed for η and A<SUB>540</SUB> as gelating above ca. 55°C, depending on θ. In HPMC solution at 2% η was dependent on the shear rate with two rotational viscometers at θ=0.70°C /min.
- 特定非営利活動法人 日本バイオレオロジー学会の論文