抵抗血管壁の力学モデルによる末梢血流調節についての考案

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In order to examine structural and mechanical influences of resistance vessel wall on the metabolic and myogenic mechanisms of peripheral flow control, a dynamic ( five-element analogue ) model for resistance vessel wall is introduced. The dynamic model here used is complex and is represented by a Maxwell model connected in series with the three-component Hill model. The metabolic effects on myogenic mechanism are inserted in Hill's contractile elements. The mechanical behavior of resistance vessel wall during autoregulatory flow control is calculated in comparison with experimental data to be explained well by the dynamic model. The elastic modulus (K<SUB>1</SUB>) of parallel elastic element and the reactivity of vascular smooth muscle are suggested to play an important role in blood flow autoregulation. In particular, the upper and lower limits of pressure in blood flow autoregulation shift to higher region of arterial pressure with the increases of the elastic modulus K<SUB>1</SUB> and myogenic contractile force so that the effectiveness of the myogenic mechanism is reduced. The wall tension is resettled at lower levels by myogenic contractile responses. (J. Jpn. Soc. Biorheol., 1 (4), 212~219, 1987).
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