追加 InsulinとGlucagonの相互作用

概要

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An investigation was made into the interaction between insulin and glucagon in the lipolysis of adipose tissue, by an in vitro experiment using epididymal adipose tissue of the rat. <BR>The lipolytic action of glucagon in a low concentration of 0.1 μg/ml was completely inhibited by the addition of 100 μU/ml of insulin, however, the lipolytic action of glucagon in a high concentration, such as 10 μg/ml, was not only uninhibited but in some instances even promoted, by the addition of insulin. Adipose tissue was pre-incubated in a medium containing 10 μg/ml glucagon, and insulin was added subsequently, however, lipolysis was not inhibited. The promotion of lipolysis of adipose tissue by the addition of dibutyryl cyclic-AMP in a concentration of 1000 μg/ml was not inhibited by the addition of insulin. On the other hand, the increased lipolysis due to the addition of theophylline was completely inhibited by the addition of insulin. <BR>From the foregoing, it may be said that glucagon promotes the action of adenyl cyclase, whereas insulin inhibits it, and consequently, there is a possibility for the strong lipolytic action of a high concentration of glucagon to be uninhibited by insulin.
一般社団法人日本内分泌学会の論文