2. ストレス及び運動の成長ホルモン分泌に及ぼす影響
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概要
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The effects of stress, exercise and other factors on human growth hormone (HGH) secretion were investigated in normal subjects and various disorders. Plasma HGH was measured by chromatoelectrophoretic radioimmunoassay.<BR>1) Exercise : Exercise by double two step test of Master was associated with a slight increase of HGH secretion only in female, but successively 6 times of the test with a remarkable increase both in female and in male. This rise of plasma HGH level was accelerated by arginine infusion or beef ingestion.<BR>2) Operation : Major abdominal surgery under general anaesthesia with Fluothane and nitrous oxide was followed by a remarkable elevation of plasma HGH with a peak at 60-90 minutes after the operation started. On the other hand, brain operation under the same anaesthesia but with hypothermia did not lead to significant changes or rather led to decrease in plasma HGH while cooling, but to a remarkable increase as rewarming commenced.<BR>3) Cold Exposure : No increase in plasma HGH level was found during exposure of normal subjects to 4°C for 1-2 hours but a significant elevation of plasma HGH level was observed following recovery to room temperature (23°C).<BR>4) Drugs : Intravenous injection of 35 mg of histamine caused a moderate increase in plasma HGH. In 6 of 8 normal subjects, simultaneous injection of aminophylline enhanced the increased response of plasma HGH by insulin-induced hypoglycemia.<BR>5) HGH secretion in primary hypothyroidism : Plasma HGH response to hypoglycemia and exercise (two step test) was significantly lower in patients with untreated primary hypothyroidism than in normal subjects.<BR>6) HGH secretion in hypopituitarism : Studies on secretion of trophic hormones in hypopituitarism showed that, of 12 patients, panhypopituitarism was found in 3 cases, partial deficiency in 8 and selective ACTH deficiency in 1. Of 9 subjects with pituitary dwarfism, panhypopituitarism was found in 1 case, partial deficiency in 5 and isolated GH deficiency in 3, of which two cases were siblings.<BR>Some cases, of which basal HGH secretion was detectable at overnight fast and suppressed by glucose administration, showed a dissociative response to various stimuli : a significant elevation of HGH level by arginine infusion despite no responses to insulin or pyrogen injection. Others showed parallel responses to such various stimuli as insulin induced hypoglycemia, arginine infusion and or exercise.
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