婦人科領域に於ける尿中ゴナドトロピンの動態特に副腎皮質機能との関連について
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概要
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Variation of urinary gonadotropin output was studied under various conditions in the gynecological area, such as oophorectomy, adrenalectomy, the administration of steroid hormones, clomiphene or triiodothyronine (T3).<BR>Urinary gonadotropin was extracted by the modified Bradbury's kaolin adsorption method and determined with the method of weighing mouse uterus. The experimental results are summarized as follows.<BR>The output of urinary gonadotropin was markedly increased in both postmenopausal and castrated women. There are, however, few cases which have shown low excretion value or daily variation. Moreover, in the postmenopausal women it tended to be higher in the sixth decade in general, but showed lower value with the increase of age.<BR>Urinary gonadotropin was not significantly increased in the premenopausal women with unilateral oophorecomy.<BR>On adrenalectomy in the patients who had advanced or recurrent breast cancer, the output of urinary gonadotropin was increased markedly after an adrenalectomy in post-menopause, but not marked in pre-menopausal women.<BR>On administering the steroid hormones in castreted women, the following results were obtained : Urinary excretion of gonadotropin was slightly decreased in 2 out of 4 cases who had received 100γ of mestranol for 8 days, while it was decreased markedly in the group which received 20 mg of norethindrone for 14 days. The suppression of output of urinary gonadotropin was more emphasized, in effect. on administering the mixed preparation of both compounds.<BR>The administration of a new ovulation-promoting agent, clomiphene, increased the urinary gonadotropin, but the synthetic thyoid hormone, T3. failed to affect the gona-dotropin noticeably.<BR>On administering ACTH (a total of 40 I.U. in 4 days) in castrated women, the output of urinary gonadotropin tended to be decreased.<BR>The effect of administration of predonisolone (30 mg for 5 days), in castrated women, was not apparent. On the other hand, a slight increase of urinary gonadotropin was obtained with administering dexamethasone (1.5 mg for 5 days).<BR>Thus, even in the postmenopausal or castrated women, urinary excretion of gonadotropin is thought to be closely related to the adrenal cortex. Therefore, a certain feed-back mechanism has been suggested between the gonadotropic activity of the anterior pituitary and the adrenal cortex, and its leading role is assumed to be accomplished by the adrenal steroids, especially so-called extragonadal estrogen.
- 日本内分泌学会の論文