合成24アミノ酸ACTHによる副腎皮質機能検査-Rapid ACTH Test

概要

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Wood et al. (1965) reports that response of cortisol secretion to single intramuscular injection of synthetic polypeptide can be used as a test of adrenocortical function. This report concerns our experience with this test carried out in 107 cases. The first blood sample was drawn at 9 a.m., immediately followed by intramuscular injection of 250 μg of synthetic 24 amino acid polypeptide (β1-24-corticotropin, CIBA 30'920-Ba). Thirty minutes thereafter, the second blood sample was taken. After centrifugation of blood samples, plasma 11-OHCS was determined by the fluorimetric method of De Moor et al.. In 21 control subjects, plasma 11-OFICS level was 9.8±3.1 μg/dl (mean±S.D.) before synthetic polypeptide injection, which rose to 20.4±4.1 /μg/dl 30 minutes after the injection. The response was subnormal or markedly suppressed in patients receiving glucocorticoid therapy, Addison's disease and Sheehan's syndrome, but it was definitely augmented in 2 out of 4 cases with Cushing's syndrome. Our experience indicates that the rapid test proposed by Wood et al. is useful as a screening test for adrenocortical function. No side effects were seen during the test procedure.
日本内分泌学会の論文