コーチゾン作用におよぼすグリチルリチンの影響
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概要
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This report deals with the effect of glycyrrhizin on the following cortisone actions : anti-inflammatory action (anti-granulomatous and anti-exudative), liver glycogen deposition, liver tryptophan pyrrolase induction, thymic involution, and suppression of antibody formation.<BR>Adult female adrenalectomized rats were used throughout the experiment but for anti-exudative action. In each experiment, animals were divided into four groups : 1) control group, 2) cortisone group, 3) glycyrrhizin group, 4) cortisone + glycyrrhizin group. After the treatment for 6 to 8 successive days, the effect of glycyrrhizin was examined on the above-mentioned cortisone actions.<BR>The anti-granulomatous action of cortisone was : demonstrated to be inhibited by glycyrrhizin using cotton pellet method. A parallel quantitative relationship was shown to exist between the dosage of glycyrrhizin and its inhibitory effect.<BR>The suppressive action of prednisolone on <I>in vitro</I> proliferation of L cell was also blocked by glycyrrhizin.<BR>The anti-exudative action of cortisone was hardly affected by concomittant administration of glycyrrhizin even in large doses following granuloma pouch method.<BR>Either liver glycogen deposition, liver tryptophan pyrrolase induction or thymic involution was significantly inhibited by glycyrrhizin.<BR>In contrast to the actions described above, glycyrrhizin was found to enhance the suppressive effect of cortisone on antibody formation against bacterial amylase as an antigen.
- 一般社団法人 日本内分泌学会の論文