胎児甲状腺刺戟ホルモンに関する研究
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概要
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For the purpose of studying the thyrotropin of the fetal pituitary gland, the following estimations have been investigated : namely, TSH production in the placental tissue, TSH variations in the fetal pituitary gland during pregnancy, passage of the placental TSH, shifting of TSH in the fetal pituitary gland and blood TSH in the newborn infant.<BR>(1) For the placental TSH extraction, Bates's percolation method seemed to be the most reliable. It was found that when TSH estimation was tried of the placental tissue with the above method, the active TSH like substance found in naturally expelled placenta was 1.7±0.4 mU/100g which was no more different than that of the tissue removed in cesarian section.<BR>In considering TSH quantity found in the residual blood volume of the placenta and that of maternal blood, it has been found that the placental TSH content did not exceed that of the residual blood. Hence, TSH is hardly secreted from the placental tissue.<BR>(2) With white mouse experiment, TSH of the pregnant pituitary was found to be markedly increased compared with that of non-pregnant period. Therefore, it is possible to assume the increased TSH in blood during pregnancy is not attributable to placental source but rather due to heightened secretion of TSH in the pituitary gland.<BR>(3) With white mouse, the experiment showed that TSH failed to pass the placental tissue.<BR>(4) It was possible to detect TSH in the anterior lobe of the pituitary of the human fetus from the 8th week of fetal life, and that the lobulation of the thyroid gland is about completed in the 23-24th week, but beginning from the latter part of the 6th gestation month and during the early week of the 7th gestation month TSH content seemed to have rapidly increased.<BR>(5) PAS positive granules seemed to appear in the anterior lobe of pituitary gland by the early week of 7th gestation month and which became more marked thereon.<BR>(6) TSH active substance value in fetal blood was found to be 4.2±1.3 mU/100 ml. It is considered that the fetal pituitary-thyroid system is engaged in an independent secretory function from that of the maternal organ.<BR>(The present paper was read by Yasuo Ueda, M.D., Professor of Obstetrics and Gynecology before The 36th Annual Meeting of Japan Endocrinological Society, and it was published in full in the Endocrinologia Japonica, Vol. 11, No. 1, 1964)
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