各種ホルモンの血中脂質に及ぼす影響特に脂肪酸輸送型について
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During short and prolonged administration of hormones and extirpation of endocrine glands in rabbits, serum non-esterified fatty acids (NEFA), triglycerides (TG), total cholesterol (Ch) and glucose (Gl) were measured, and changes in NEFA and Gl levels during glucose tolerance test before and after treatments were studied.<BR>Fatty acid mobilizing effect was demonstrated by an increase of NEFA and TG after a short administration of hormones.<BR>1) Adrenalin showed a fatty acid mobilizing effect, but the elevations of serum NEFA and TG levels were inhibited by marked hyperglycemia which followed.<BR>2) Administration of insulin caused a rapid fall in the serum levels of NEFA and glucose. The decreased NEFA levels returned to fasting levels more quickly than glucose.<BR>3) Thyroid hormone showed a fatty acid mobilizing effect and conditioned the adipose tissue to an increase of NEFA release. Decrease of fasting lipid levels in the serum and glucose intolerance which were produced by the prolonged administration of this hormone, were due apparently to the increased utilization of fatty acids in the peripheral tissue.<BR>4) Estrogen was not effective on the fatty acid mobilization and the glucose tolerance, but decreased the fasting levels of serum lipid. On the other hand, ovariectomy caused a increase of fasting lipid levels in the serum and glucose intolerance.<BR>5) Androgen conditioned the adipose tissue to an increase of NEFA release and decreased the fasting levels of serum lipids. Orchectomy caused a glucose intolerance, a decreased inhibition of NEFA release in glucose load and an increase of serum lipids.<BR>6) Glucocorticoid showed a fatty acid mobilizing effect, in particular hypertriglyceridemia, hyperglycemia and glucose intolerance. Increase of NEFA release produced by this hormone was inhibited by the hyperglycemia which followed.<BR>7) ACTH showed a marked fatty acid mobilizing effect and a glucose intolerance, and simultaneously conditioned the adipose tissue to an increase of NEFA release.
- 日本内分泌学会の論文
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- 各種ホルモンの血中脂質に及ぼす影響特に脂肪酸輸送型について