食塩摂取量と尿中Aldosterone排泄量

概要

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Aldosterone excretion in urine and salt concentration in serum were studied on 4 subjects on different intakes of sodium chloride. Results obtained were as follows ; 1) Daily output of aldosterone in urine increase remarkably on low sodium diet and decrease on high sodium diet. The other corticoid, such as, 17-OHCS and 17-KS is maintained constant irrespective of salt intake. 2) An inverse correlation is found between the aldosterone output in urine and the logarithm of dose of Na content in urine. The K/Na ratio bear a good positive correlation with the aldosterone output. Remarkable individual difference were found in the correlationships. 3) Na and Cl concentration in serum increase on high sodium diet and decrease on low sodium diet, while K concentration in serum is maintained constant. 4) The change of Na concentration in serum seems to bear important factor which governs aldosterone excretion.
日本内分泌学会の論文