経口糖尿病治療剤投与時に於ける糖中間代謝に関する研究

概要

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Since the discovery of insulin in 1922, much progress has been made in the therapy for diabetes mellitus. However, insulin has its limitations in that it can be used only by means of injections.<BR>For a long time, we have been looking forward to the discovery of a per oral medicine which would be applicable. Recently, various per oral medicines have been discovered : mesoxan, sulfonylurea and biguanide. However, there are divergent opinions among the researchers throughout the world regarding the mechamism of hypoglycemic action of these medicines.<BR>At the Congress of the Japanese Society of Internal Medicine, Professor Hideo Yoshida of our Medical Department reported on the mechanism of sulfonylurea. (1958) At the Congress of the Japanese Endocrinological Society, Professor Hideo Yoshida et al. reported on the mechanism of biguanide. (1961) <BR>My present study not only covers the influence of these per oral medicines on carbohydrate metabobolism, especially pyruvic acid and lactic acid, but also on the effect of glucose tolerance test.
日本内分泌学会の論文