Vasopressin の甲状腺機能に及ぼす影響について
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概要
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The effect of vasopressin on the thyroid activity was studied in rats, measuring T/S ratio, thyroidal <SUP>131</SUP>I uptake and serum PB<SUP>131</SUP>I.<BR>Neither single doses of Pitressin, 60 mU. per 100 gm. body weight, nor successive administrations of Pitressin tannate, 100 and 400 mU. per 100 gm. body weight daily for 3 days, caused any significant change in the T/S ratio in rats kept at 20°C. Exposure of rats to a cold environment of 10°C for 1 week resulted in a marked increase in the T/S ratio as well as the thyroid gland weight. Chronic treatment with Pitressin in a dose of 40 mU. per 100 gm. body weight twice a day during the period of cold exposure brought about a suppression of the rise in T/S ratio due to cold exposure.<BR>The serum PB<SUP>131</SUP>I level was maintained at approximately the same level during the period of repeated blood collections which was possibly due to minor surgical stress of blood collection. Pitressin in a dose of 100 mU. per 100 gm. body weight but not synthetic lysine vasopressin, caused a progressive decrease in the serum PB<SUP>131</SUP>I level. After hypophysectomy the serum PB<SUP>131</SUP>I level decreased progressively with time. Pitressin had no effect on this decrease of PB<SUP>131</SUP>lI in these rats. In hypophysectomized rats, the rise of PB<SUP>131</SUP>li followed by exogenous TSH, 50 mU. per 100 gm. body weight, was suppressed by the simultaneous administration of Pitressin, 100 mU. per 100 gm. body weight, but not by that of synthetic lysine vasopressin.<BR>Administration of ACTH, methylthiouracil, epinephrine, Dibenzline, and Ismelin as well as adrenal medullectomy did not affect PB<SUP>131</SUP>I level under the conditions used.
- 日本内分泌学会の論文