血糖変動時の尿中Catecholamineの消長に関する研究
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概要
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It has been well established that catecholamine excretion in urine increases after insulin administration ; and the reduction of blood sugar below the normal range is considered to be the stimulant of catecholamine secretion. However, the hypoglycemic syndrome is occasionally encountered under insulin treatment of diabetics even when the blood sugar remains within normal range, and it is reasonably assumed that there is an increased discharge of catecholamine under such a condition. In this report, the relation between blood sugar variation and the excretion of catecholamine was analysed in normal subjects and patients with various severities of diabetes mellitus. The mechanism of increasement of catecholamine excretion was also investigated. The results were as follows : <BR>1) The folds of increment in catecholamine excretion after the intravenous administration of insulin of 0.1 unit/kg to normal or diabetic subjects is significantly well correlated with the value represented as the following equation ;<BR>(blood sugar before administration) / (minimum blood sugar value) (blood sugar before administration) x (minutes from adm. to minimum) <BR>2) The transient increase of urinary catecholamine metabolites such as Metanephrine or Vanillylmandelic acid is observed in the early period of the treatment of diabetics with insulin or antidiabetic sulfonylurea.<BR>3) The data was obtained in animal experiments, suggesting that the adaptation of the central nervous system to hypoglycemic state is the cause of the increased excretion of catecholamine observed in diabetics when the blood sugar remains within normal range after insulin administration.
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