大脳辺縁系刺激の甲状腺ホルモン分泌機構に及ぼす影響

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The regulation of pituitary-thyroidal function through the central nervous system has been the subject of many studies, most of them dealing with the hypothalamus. The limbic system has been known to play an important role in autonomic nervous regulation, and recent studies at several laboratories have revealed that this part of the brain has an intimate relation to corticotropic and gonadotropic secretion. The effect of electrical stimulation of the posterior orbital surface on pituitary-adrenocortical function has been reported from our laboratory. With respect to the secretion of TSH, however, a definite relationship has not been established. Yamada and Greer reported that bilateral destruction of amygdaloid nuclear complex had little effect on PTU induced goitrogenic action. In this paper the effect of electrical stimulation of the limbic system on the pituitary-thyroidal function in dogs is reported. Stimulation of the amygdaloid nuclear complex, the posterior orbital surface and the hippocamp formation was induced in morphine anesthetized dogs which had been previously labelled with I131. In each of four cases in which the posterior orbital surface and the amygdaloid nuclear complex were stimulated, there was no significant increase in the concentration of PBI131 and inorganic I131 in the thyroid venous blood. In 10 cases in which the hippocampal formation was stimulated, a definite increase in both of organic and inorganic I131 in the thyroid venous blood was observed with no significant change in the thyroid venous blood flow. Significant increase in the TSH content of the jugular vein blood, assayed in 4 animals by McKenzie's method, occurred in all cases within 30 minutes. Hypophysectomy prevented the response of the thyroid to hippocampal stimulation.
日本内分泌学会の論文

大脳辺縁系刺激の甲状腺ホルモン分泌機構に及ぼす影響

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