Abnormal TSH の臨床的研究
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Using Noguchi's modification of McKenzie's method for bioassay of thyrotropin, which depends on the release into the circulating blood of radio-iodine from thyroid gland of mice, an attempt was made to measure thyrotropin in human serum. The following results were obtained : <BR>1) The abnormal thyroid stimulator in serum from hyperthyroid patients is distinguished from the standard thyrotropin preparations by its prolonged action in assay. It was sought in the serum of 96 patients with hyperthyroidism and was found in 17 of 25 untreated patients.<BR>2) The level of the abnormal thyroid stimulator showed a falling tendency after teatments by the merkazole (1-methyl-2-mercaptoimidazole), Lugol s solution or thyroidectomy.<BR>3) No specific correlation was found between clinical symptoms and the level of abnormal thyroid stimulator in hyperthyroid patients.<BR>4) The abnormal thyroid stimulator was measured before and 24 hours after the thyroidectomy but no significant change was observed.<BR>5) There was no significant difference in the level of the abnormal thyroid stimulator between arterial and venous blood of the thyroid.<BR>6) The abnormal thyroid stimulator was found in only one of six hyperthyroid patients with diabetes mellitus.<BR>7) The level of the abnormal thyroid stimulator showed fairly good correlation with the epithelial proliferation of the thyroidal follicle in the specimen presented at the time of thyroidectomy.
- 一般社団法人 日本内分泌学会の論文
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- Abnormal TSH の臨床的研究