脳腫瘍患者の副腎皮質機能に関する臨床的研究

概要

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In order to obtain the indicator endocrinologically for the improvement of pre-, per, and postoperative procedures against brain tumor in patients, 69 cases of these cases were examined concerning their pituitary-adrenocortical functions. In these series, ACTH-Z test was employed to measure the adrenocortical responses quantitatively through urinary 17-OHCS. For the estimation of preoperative status, "Adrenocortical response to Corticotropin, " (Acr-C), and for the postoperative career, "Adrenocortical response to Operation, " (Acr-O), and "Adrenocortical response-Index", (Acr-I) were devised through the measurement of urinary 17-OHCS respectively.<BR>1) In normal subjects, Acr-C range was 8.0-42.0 mg. In 69 brain tumor patients, 3 groups were classfied ; 14 cases showed hypo-reactive, 11 cases showed hyper-reactive and others were normo-reactive responses. The hyper-reactive responses are considered to be a specific phenomenon observed among the brain tumor cases.<BR>2) The evidence by the measurement of Acr-O, and Acr-I showed a remarkable decrease of the adrenocortical response it those brain tumor cases who had undergone operations under artificial hibernation as compared with those patients under normothermic anesthesia.