糖尿病前症に関する研究

概要

論文の詳細を見る
Many reports have been presented on the statistics or diagnosis of prediabetes, but fewer studies have been attempted to elucidate the metabolic or hormonal disturbance in prediabetes. The present study was carried out in order to make some of these subjects clear. The fluctuations of blood inorganic phosphorus and Δ7P after the administration of cortisone-glucose or insulin were less marked in prediabetics than that in normal subjects. The phosphorylation rates of vitamin B1 and B6 in the blood after the administration of these vitamins were lower in prediabetics than that in normal. Some prediabetics showed a decreased insulin sensitivity, and the plasma insulin level distributed in the wide range in prediabetics, as well as in normal or diabetics. The decreased insulin sensitivity of prediabetics who has the high plasma insulin level was corrected by the use of pyridoxal phosphate, but that of prediabetics who have the low plasma insulin level was not corrected. Furthermore, prediabetics with a high plasma insulin level were found among the family having the diabetic with the high plasma insulin level, and vice versa. These results suggest that prediabetics, as diabetics, are divided into the two types ; one type, in which the insulin utilization is disturbed, and another type, in which insulin is lacking. In addition to that, the type of diabetes may be decided by the hereditary disposition.
日本内分泌学会の論文