インシュリン活性とビタミンB<SUB>6</SUB>の関連
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概要
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It is generally known that there is some evidence suggesting an intimate relationship between vitamin B<SUB>6</SUB>, and diabetes mellitus. But almost nothing is known regarding the relationship between the action of insulin and vitamin B<SUB>6</SUB>. In my study on this subject, I obtained the following results.<BR>1) The cause of the diabetic state in rats, being fed a diet over a 2-to 3-month period in which vitamin B<SUB>6</SUB> was eliminated, may be attributed to the disturbance of insulin utilization but not to the xanthurenic acid which is produced during the deficient period.<BR>2) The diabetic state in rats, being fed a diet over a 9-month period, in which vitamin B<SUB>6</SUB>, was restricted to doses only sufficient to sustain life, is due to a lack of insulin.<BR>3) It is conceivable that, one of the many factors contributing to the disturbance of insulin utilization has some relation with vitamin B<SUB>6</SUB>, or the vitamin B<SUB>6</SUB> enzyme, because the disturbance of insulin utilization in diabetic patients with a high plasma insulin level is often corrected by the use of PAL-PO<SUB>4</SUB>. Furthermore, the use of pyridoxine for the disturbance of oxydative phosphorylation in diabetics is not effective, the only effective agent being PAL-PO<SUB>4</SUB>, which is the co-enzyme of pyridoxine.<BR>These results clearly evidenced the intimate relationship between vitamin B<SUB>6</SUB>, and diabetes in man. In conclusion, it is not the purpose of this report to emphasize the significance of PAL-PO<SUB>4</SUB> for the treatment of some types of diabetes, but to assert that vitamin B<SUB>6</SUB> is an important key for the resolution of the etiology and pathological physiology of diabetes mellitus.
- 一般社団法人 日本内分泌学会の論文