3-methoxy-4-hydroxymandelic acidの尿中排泄について:1. Sandler's methodの批判

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In reference to microdetermination of catecholamine, our efforts in the past few years have been concentrated on estimation of free catecholamine in urine or plasma, however the detection has so far met with certain difficulties.<BR>Recently, Armstrong reported that 3-methoxy-4-hydroxymandelic acid was excreted in urine as a major metabolite of epinephrine and norepinephrine. Following this, some methods for estimation of 3-methoxy-4-hydroxymandelic acid in urine have presented.<BR>We have followed Sandler's method without delay and partially modified as well as simplified the entire procedure and we have found it diagnostically significant in clinical application.<BR>In brief, we employed the "omitting of indol reagent" -technique as a blank preparation. We invite your suggestion for our modification.
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