抗結核剤, 副腎皮質ホルモン併用投与時のVB2代謝

概要

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In this study, Vitamin B2 level of normal rat liver was measured by means of Fujita and Matsuura's lumiflavin fluorescent method under the administrations of antituberculosis drugs, that is, SM, PAS and INH, and moreover, the poly-administration of them and adrenal cortical hormone. The results obtained are summarized as follows : 1) The group injected with SM at the rats of 0.25 mg/day for 20 days showed remarkable decrease of the Vitamin B2 level, compared with the control which was injected with physiological salt solution for the same term. There was no change if Predonine and SM were administered at 0.25 mg/day at the same time. 2) Under repeated injections of PAS at 100 mg/day for 20 days, Vitamin B2 decreased, but there was no change after the poly-administration of Predonine at 0.25 mg, as in the case of SM. 3) The groups injected with INH at 2.5 mg/day for 20 days, and at 5 mg/day for 10 days showed no difference from the control. There was no change from repeated poly-administration of Predonine at 0.25 mg. 4) Hence, Vitamin B2 decreased under repeated poly-administration of 50 mg SM and 100 mg PAS. 5) A decrease was also shown under repeated poly-administrations of 5 mg INH and 100 mg PAS for 10 days. Taking these facts into consideration, it is concluded that Vitamin B2 level of the liver decreases in all other cases except that of INH only, and Predonine brings no change to the decrease.
一般社団法人日本内分泌学会の論文