視床下部破壊に依る下垂体-甲状腺系の実験的研究

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In the present study, the effect of hypothalamic lesions on the 131I concentration by the posterior pituitary, and median eminence, and neurosecretory phenomena, was investigated to elucidate the hypothalmo-hypophyseal control of the thyroid. The following results were obtained : Unilateral anterior hypothalamic lesions reduced the 131I concentration in the posterior pituitary and median eminence, and greatly inhibited the hypothalamic neurosecretory function and TSH secretion by the anterior pituitary, although, 3 days after their destruction, these functions were accelerated, as shown by rebouned phenomena reported by D/Angelo et al. In bilateral anterior hypothalamic lesion animals, there was a remarkable reduction in the 131I concentration in these tissues and the function of neurosecretion and TSH secretion by the anterior pituitary. From these findings, the anterior hypothalamus was considered to play a role in the regulation of the pituitary-thyroid axis. On the other hand, neocortex did not directly affect the function of the system.
一般社団法人日本内分泌学会の論文