歴代甲状腺末投与雌, 雄ウサギより生まれた子孫ウサギ (F4～F6) の病理学的研究

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Kuramochi reported that a tendency toward thyroid hyperactivity could be brought about successively in the offsprings F1, F2 and F3 of rabbits, when they were mated after being fed powdered thyroid glands (thyradin) in a dose of 30 mg per kg daily for a period of over one month. This type of experiment was continued up to the F6 generation by the author. 21, 17 and 17 rabbits in the F4, F5 and F6 generations respectively were the materials used in this report. Among them 5, 5 and 6 rabbits in the F4, F5 and F6 respectively were used in attempt to do, histological and histometrical examinations of the thyroid, pituitary, adrenal glands and other organs. Other 6 rabbits were fed the powdered thyroid glands and subjected to the same examination. These results were compared with those from 12 normal rabbits : A. In the non-medicated group of F rabbits ; I. Body weight : The rate of growth in the F4, F5 and F6 was almost normal or slightly subnormal. 2. Thyroid gland : (i) The gland became heavier in weight than the normal with a tendency toward gradual increase with successive generation, resulting in two times of the normal weight in the F6. (ii) The ratio of the glandular weight to the body weight showed almost the similar tendency and in the F6 2.5 times of ratio of the normal was obtained. (iii) The area of follicles was much smaller than the normal, and decreased in size as the generations descended further. (iv) The area of follicular lumina was also much smaller than the normal, being accompanied with gradual decrease in size in successive generations. And in many cases of F6, the follicles showed parenchymal architecture due to the loss of the lumina, and some showed papillary pattern. (v) These follicles were round, oval or irregular in shape. (vi) The follicular epithelial cells changed from low to high cubic, and finally to cylindrical cells with nuclei in their center, due to augmentation of the area and height taking place successively in the F4, F5 and F6. (vii) Epithelial cells of one follicle were few in number than the normal, with gradual decrease in successive generations, and became one half of the normal in the F6. (viii) The colloid substance in the F4, F5 and F6 became less in amount and was stained with eosin in less extent, and in some cases loss of colloid substance was observed. (ix) Blood congestion of the interstitial vessel was found frequently. 3. Other organs : (i) In successive generations, the basophilic and eosinophilic cells increased in per cent and the chromophobic cells decreased in the anterior lobe of the pituitary gland. (ii) Slight decrease in weight of the adrenal gland, obscurity of boundaries of the each cortical zone, atrophy and irregularity of the zona fasciculata and (iii) congestion in the liver, slight atrophic change of the gromeruli in the kidney were found in the F animals. B. In the medicated group of the F rabbits, the following results were obtained : 1. Thyroid gland : (i) The weight and the ratio of the glandular weight to the body weight were less than the normal (ca. one half). Almost no thyroid tissue could be found in one case due to fatty changes of the tissue. (ii) The area of follicles and of lumina increased in size. (iii) The follicles were round or oval in shape. (iv) The area of the epithelial cells decreased in size and the cells became flat. (v) The cells forming follicles increased in number. (vi) The colloid substance was abundant and was stained often with strong eosinophilic tendency. 2. Other organs : (i) In the anterior lobe of the pituitary gland,
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中島養郷
京都大学医学部病理学教室大学院

歴代甲状腺末投与雌, 雄ウサギより生まれた子孫ウサギ (F<SUB>4</SUB>～F<SUB>6</SUB>) の病理学的研究

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