BZ55 (Carbutamide) 作用機序に関する研究:BZ55の代謝を中心として

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BZ55 (carbutamide) has been studied in vitro and in vive as a series of the experiment on the hypoglycemic mechanism of sulfonylurea.<BR>1) BZ55 administered to rabbit was recovered for the most part in the body fluid and the excretion of the agent to be dependent on the kidney on the fact of high concentration of acetylation of the drug in the organ.<BR>2) The rate of metabolic destruction of BZ55 and the concentration of blood sugar showed to be in a reverse relation and no correlation was found between the blood sugar level and the concentration of the drug in the blood. Thioctic acid, small dosis or large, administered in combination with BZ55 revealed a similar result as by BZ55 alone in connection with the blood sugar level.<BR>3) BZ55 was found to a large extent bound with red cell protein in an hour after the administration of the drug and the amount bound with the protein was decreased in proportion to the severity of alloxan diabetes.<BR>4) BZ55 that appeared to be metabolised in the medium added with red blood cell, plasma or Ringer's solution and the metabolism was facilitated by an unknown substance (probably insulin) in the plasma added.
一般社団法人日本内分泌学会の論文