血清インシュリン活性並びにインシュリン拮抗因子からみた糖尿病に関する研究
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概要
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Diabetes mellitus is a disease characterized by various metabolic disturbances primarily due to the relative or absolute deficiency of insulin in the body. In the present study, serum insulin activity was measured using rat diaphragm by Willebrands' method and was compared with various metabolic changes. Favorable response to the treatment of sulfonylureas was seen in patients showing extra-insulin secretion after the intravenous glucose loading. Anti-insulin factors were also investigated in severe diabetics and normal individuals and subclinical alloxan-diabetic and adrenalectomized rabbits treated with typhoid vaccine.<BR>The results are summarized as follows : <BR>(1) Contrary to the conclusion of Lawrence and his associates, low serum insulin activity was observed in about 60% of maturity-onset diabetics.<BR>(2) Diabetics with infection or increased urinary excretion of ketone bodies showed generally diminished serum insulin activity.<BR>(3) Close negative correlation was found between serum insulin activity and the 2nd hour level of blood sugar following glucose loading, although no significant correlation was found between serum insulin activity and the fasting blood sugar level or serum total cholesterol.<BR>(4) Acetylating activity of p-aminobenzoic acid was decreased in patients with low serum insulin activity.<BR>(5) Approximate linear relationship between regression coefficient following intravenous glucose loading and serum insulin activity was demonstrated in healthy subjects and in mild and moderate diabetics.<BR>(6) Oral antidiabetics such as sulfohylureas and mesoxalate were not effective in diabetics with low serum insulin activity, but biguanides were effective in most diabetics with low serum insulin activity as well as those with high serum insulin activity.<BR>(7) Secondary failure of sulfonylurea treatment developed more rapidly and more frequently in diabetics with low extra-insulin secretion.<BR>(8) Adrenal glands seemed to have relation with anti-insulin factor in the sera of untreated severe diabetics and rabbits treated with typhoid vaccine.
- 一般社団法人 日本内分泌学会の論文