歴代実験的糖尿病子孫ウサギおよびWistar系シロネズミの尿中ケトステロイド, ウロペプシンの排泄状態ならびにアロキサン投与による影響こついて
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Measurement of a total of 17-KS and its fractions excreted in the urine was made on the rabbits obtained from the diabetic parents by successive mating for seven or eight generations. Some of these rabbits were under the examination 50 to 365 days after an additional treatment with alloxan was employed. The following results were demonstrated, comparing with the data from control rabbits with or without alloxanization.<BR>a) In the rabbits born from the sicked parents an increase in amount of 17-KS and II, III, VI, VII fractions were observed. The increase became more apparent with the successive mating generations and it was very marked in after the fourth generation in which spontaneous diabetes developed.<BR>b) Amounts of 17-KS and its II, III, VI, VII fractions in the intact rabbits became under the normal levels when diabetes developed after administration of alloxan.<BR>c) Amounts of 17-KS and its II, III, VI, VII fractions excreted in the urine in the rabbits born from the sicked parents up to the second generation showed a decrease after alloxan administration, which were larger than those excreted in the urine of the alloxanized control rabbits and which were smaller than those of normal rabbits. However, in the rabbits from the sicked parents from the third to the fifth generations of the successive mating, a decrease in amounts of 17-KS and its II, III, VI, VII fractions was resulted from alloxanization, remaining at the level above normal ranges.<BR>Measurement of a total amounts of 17-KS and its fractions, FGS and uropepsin were made on the following animals (I) the first group, Wistar rats with spontaneous diabetes in both sexes born from the spontaneous diabetic parents, at definite intervals of time from the weanling age to approximately 120 days of age. (2) the second group, some of the male rats of the first group, exposed to alloxanization when the animals showed negative urine sugar. The following results were obtained, comparing with the data from normal rats with or without alloxanization.<BR>a) In Wistar rats of the first group, larger amounts of 17-KS and its II, III, VI, VII fractions, FGS and uropepsin were excreted in the urine than those in the normal rats during a full course of maturation and aging since weanling age.<BR>b) In normal rats with alloxanization, an increase in amount of the metabolites mentioned herein observed 10 days after the treatment was followed by a persistent decrease.<BR>c) The male rats in the second group, alloxanization also resulted in a temporary increase in the urinary amounts, subsequently followed by a decrease, continuing for at least 3 months, amounts in the decreasing stages still being remained in over normal ranges.<BR>The following conclusions may be obtained from the results mentioned above : <BR>1) In the offspring rabbits and Wistar rats born from diabetic parents, the hyperfunction of the adrenal cortex can be observed, the degree of which being gradually more apparent with successive mating generations.<BR>2) The hypofunction of the adrenal cortex can be developed in the animals when rabbits and Wistar rats were became diabetic by application of alloxan.<BR>3) The offsprsng animals born from the diabetic parents, when alloxanization is employed, show various function states, from hyper- to hypo-function to less extent, corresponding to the generation number of the successive mating.
- 一般社団法人 日本内分泌学会の論文
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- 歴代実験的糖尿病子孫ウサギおよびWistar系シロネズミの尿中ケトステロイド, ウロペプシンの排泄状態ならびにアロキサン投与による影響こついて