糖尿病患者のD860 Response Testについて

概要

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The following results were attained by intravenous administration of 0.5 g. D 860 in diabetics. <BR>(1) In normal subjects, blood sugar level was decreased to the lowest, in average mean 43% reduction from the initial value in 30 min. and restored to the intial level in 120 min.. In diabetics, however the decreased rate in 30 min. was 23% in effective cases of D 860 oral therapy, while only 10% in non-effective cases, and blood sugar level was shown the continuous slow decline without restoration until 120 min.. <BR>(2) This D 860 response test therefore might be appriciable to differenciate between non diabetics, likeweise to predict the effectiveness of D 860 therapy per se. <BR>(3) It was also found that the blood sugar curve following D 860 intravenous administration was quite similar that of insulin administration. This fact suggested that insulin would be released from Langerhans' island by D 860, however it was not negligible that extrapancreatic factors might be contributed to the mechanism of reduction of blood sugar level by this drug.