糖尿病の適応代謝異常に関する研究

概要

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Derangement in metabolism was studied on 59 slight cases of obese diabetics. Predominance of these cases is characteristic after the close of World War II. Metabolic observations were made on diurnal alteration and responsive changes to stress in these patients and the following results were obtained.<BR>1) Concomitant retarded response in protein metabolism was observed with retardation in carbohydrate metabolism. Following the recovery in carbohydrate metabolism after two successive injection of insulin, normalization in protein metabolism was also observed. However, derangement in circulating eosinophils, serum iodic acid value, and water content of blood was still observed in spite of the blood sugar being regulated to the level characteristic for each individual.<BR>2) Decrease in circulating eosinophils was observed in instances where the blood sugar level was heigh and in instances where blood sugar level was controlled, the circulating eosinophils tended to be increased gradually to normal levels.<BR>3) In normal subjects, response to stress was observed to be stronger after injection of ACTH as compared with intravenous injection of glucose. In diabetics, this was observed to be visa versa. These results lead to the presumption that the adrenocortical system of diabetics is not in the hypo-functional state.
日本内分泌学会の論文