Corticoidsと蛋白との結合並にその臨床的意義に関する研究

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The binding of corticoids with plasma protein was studied with the methods of dialysis equilibrium, paper electrophoresis, ultraviolet absorption and deproteinization, and the significance of its binding was discussed from the clinical view point. The results obtained are as follows : 1) Plasma free 17-hydroxycorticosteroids bind almost with plasma protein, chiefly α-globulin and albumin, physiologically. But cojugated 17-hydroxycorticosteroids bind at the lower rate. At the high concentration of corticoids in plasma after the administration of cortisol in vivo or in vitro, the binding ratio decreased remarkably. 2) The protein binding of corticoids is very loose and easily affected by alterations of medium pH, corticoid concentration and presence of organic solvents. 3) The corticoids dissociated from the binding with protein have the biological activity. 4) Protein bound corticoids seem to be protected form the degradation in the liver. 5) It may be expained by the protein binding of corticoids that the renal clearance rate of free corticoids is very low. 6) The binding state is considered as "corticoid pool" which keep off the degradation of corticoids in the liver and the excretion from the kidney.
日本内分泌学会の論文