血清及び尿中Donaggio活性ムコ蛋白変動の相互関係殊にstressに於ける検討
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概要
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In certain diseases or stresses, it was reported that the increased levels of mucoproteins in serum and increased excretions of urinary mucoproteins were observed. However, very little has been known regarding the relationship between mucoproteins in serum and urine. In this paper, Donaggio-active mucoproteins in serum and urine were estimated by Ishihara's methods and the following results were obtained.<BR>1. Levels of serum mucoproteins in 118 cases of tuberculosis, 4 cases of exsudative pleuritis, 3 cases of pneumonia, 12 cases of cancer, and 9 cases of gastric ulcer were higher than those levels of 23 cases of healthy subjects.<BR>2. Donaggio-active mucoprotein levels in serum were correlated well with 24-hour-excretions of Donaggio-active mucoproteins in 45 cases.<BR>3. No diurnal variations of Donaggio-active mucoproteins in serum were observed in 6 cases of healthy subjects and one case of far advanced tuberculosis, while obvious diurnal variations were observed in urinary Donaggio-active mucoproteins.<BR>4. No daily variations of Donaggio-active mucoproteins in serum were observed in a healthy sub-ject and a patient with far advanced tuberculosis, however daily urinary outputs of mucoproteins were exhibited considerable variations.<BR>5. In 3 cases of healthy subjects, administrations of ACTH gel (40 Armour units) induced a significant increase of Donaggio-active mucoproteins in urine, while levels of Donaggio-active mucoproteins in serum didn't response even to ACTH.<BR>6. Five healthy males are subjected to observe the effect of hydrocortisone. Levels of mucoproteins in serum of 3 cases were elevated following oral administration of hydrocortisone, and no changes were shown in urinary excretions of Donaggio-active mucoproteins. Levels of Donaggio-active mucoproteins in serum of remaining 2 cases were not elevated, and excretions of Donaggio-active mucoproteins in urine were increased significantly.<BR>7. The effects of surgical operation were investigated on 5 cases of gastric ulcer, one case of gastroduodenal ulcer and 2 cases of osteosynthesis. Postoperative levels of Donaggio-active mucoproteins in serum were constant in 4 cases, elevated in 2 cases and indefinitely variable in remaining 2 cases. However Donaggio-active mucoproteins in urine were remarkably increased after operation in all cases.<BR>8. Muscular exercises were performed using bicycle ergometer in 5 healthy subjects. Except one case, muscular exercise didn't affect the levels of Donaggio-active mucoproteins in serum, while excretions of Donaggio-active mucoproteins in urine were increased significantly. In a case excluded, the levels of Donaggio-active mucoproteins in urine was less than those of 4 cases.<BR>In general, Donaggio-active mucoproteins in serum were shown high levels in patients with tuberculosis, pneumonia and cancer. Enhanced excretions of Donaggio-active mucoproteins in urine were also concomitant occurence in these cases. Following administration of ACTH and in such stressed conditions as surgical operation and muscular exercise, Donaggio-active mucoproteins in serum were kept relatively constant, while the outputs of Donaggio-active mucoproteins in urine were increased significantly.<BR>It is of interest to note, in conclusion, that there are distinguishable patterns in the changes of mucoproteins in blood and urine between "stress" and certain diseases where some abnormalities in mucoprotein metabolism have been reported.
- 一般社団法人 日本内分泌学会の論文