妊娠時におけるInsulin感性

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This work, the insulin sensibility of the pregnant, has been performed as a part of the co-operative investigation in our department concerning the carbohydrate metabolism in the pregnant woman. In accordance with the modified Radoslav's method the blood was taken every 10 minutes after a single injection of 5 units of insulin intravenously eary in the morning on an empty stomach. The blood sugar was estimated by the Somogyi's Anthron method. The insulin sensibility coefficient of the pregnant was proved to be lowered, as compared with the non-pregnant, moreover declining much more as the month of pregnancy proceeds. Regarding to the rate of covery it was almost the same in both groups. Next, the I/G ratio in the modified Himsworth's method, namely the indicator of insulin sensibility, was proved to decline month after month in pregnacy. The inorganic phosphate in blood was estimated by the Nakamura's method after the intravenous administration of insulin according to the modified Radoslav's method. The decreasing rate of the inorganic phosphate in blood caused by the insulin administration was proved to get lowered in the pregnant comparing with that of the non-pregnant. This may indicate that the vicissitudes of the inorganic phosphate in blood run almost pararell with that of blood sugar. In conclusion, the results obtained above may suggest that the insulin tolerance must increase in the pregnant, and it could be inferred, as the interpretation of this cause that the fluctuations of the functions of the pituitary-adrenocortical system would have something to do with it.
日本内分泌学会の論文

妊娠時におけるInsulin感性

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