甲状腺機能亢進症におけるPBIの臨床的観察
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概要
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PBI, BMR, I Uptake, pulse rate, nutritional condition and serum cholesterol were measured in 34 cases with hyperthroidism including 12 males (2 cases in 20s, 7 cases in 30s, 3 cases in 40s) and 22 females (9 cases in 20s, 5 cases in 30s, 7 cases in 40s, 1 cases in 50s). The relationship between PBI and observed values of various tests was investigated taking the differences due to age and sex into consideration. Besides, in 3 cases successfully treated with I, the changes toward normal of PBI, BMR and uptake were observed in accordance with the favourable progress of the disease.<BR>PIB, BMR and uptake were determined on 51 cases of healthy male subjects (22 cases with ages of 20-39 years, 29 cases with ages of 40-69 years) and 38 cases of healthy female subjects (18 cases with ages of 20-39 years, 20 cases with ages of 40-69 years) who were chosen as cotrols. BMR, PBI and uptake were all higher in hyperthyoidism than in healthy subjects, however, no particular differences according to sex were observed in any of the above 3. PBI and uptake in the presence of equal degree of BMR in hyperthyroidism showed the same tendency as among healthy individuals in that the observed values were lower in the age group of over 40 years as compared to the age group of below 39 years, although there were no differences in BMR both in healthy subjects and patients with hyperthyroidism between above two groups. In regard to the relationships between the age groups of below 39 years and over 40 years coincided and showed the same correlation regardless of age. On the other hand, the two regression lines between PBI and BMR did not coincide according to age and as a result significant difference was observed.<BR>If BMR represents the absolute value of basal metabolism expressed interms of calorie per square metre body surface, PBI shows a better correlation with BM than with BMR, in both healthy persons and patients with hyperthyroidism. Therefore it can be said that, BM reflects PBI better than BMR in grasping the extent of hyperthyroidism.<BR>There was no observable fixed tendency in the relationships between PBI and nutritional condition and also between PBI and serum cholesterol.<BR>It has been observed that treatment by I decreases PBI, BMR and uptake toward normal in hyperthyroidism. Although, PBI and BMR especially correspond with the improvement of symptoms, some of the cases show still high values of uptake in spite of the improvement of various symptoms. It was observed that return to normal of uptake was generally slower than PBI and BMR.
- 日本内分泌学会の論文