Methylandrostenediolの生理作用とその臨床的応用
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概要
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Recently, the value of therapeutic application of androgenic hormones to various diseases as to protein anabolism has been stressed. However, more precise knowledge of these hormnes are required to obtain therapeutic success without appreciable side effects. In the present study, some of the physiologic effects of 17 alpha-methylandrostenediol (MAD) has been studied. The influence of this hormone on the course and the metabolic aspects of patients suffering from chronic diseases, has been also studied.<BR>1) MAD caused increase in the rate of growth. The weight of liver and kidney also increased with simultaneous rise in the activity of catalase of the liver. MAD could alleviate the inhibitory effect of 1% Niacinamide added to the ration upon the growth of young rats.<BR>2) MAD caused decrease in the urinary excretion of derivatives of nicotinic acid, while the hepatic concentration of DPN and DPNH remained essentially the same and total amount of hepatic DPN increased due to the increase in liver weight. Large amount of MAD caused increse of urinary excretion of niacin derivatives when administered daily for several days.<BR>3) MAD caused decrease in the serum level of total cholesterol and phospholipid in adult rats. However, the cholesterol content of the liver increased with simultaneous increase in phospholipid.<BR>4) MAD could relieve the inhibition in growth of rats caused by repeated injection of carbon tetrachloride. Histologic changes were found to be less in rats treated with MAD compared with those of controls damaged with carbon tetrachloride.<BR>5) MAD was also effective in improving the metabolic abnormalities in rats treated with mercuric chloride.<BR>6) 30 to 75mg. of MAD were administered to patients with chronic diseases daily intramuscularly.<BR>a) Increase in the amount of urine with improvements in subjective complaints was noted in 7 out of 8 cases of nephrotic syndrome, although, the amount of urinary albumin did not show marked change. Abnormalities in serum lipids were found to be improved in patients with favorable clinical response.<BR>b) MAD caused more marked improvement in muscle strength in patients with progressive muscular dystrophies when administered as an adjunct to amino acid treatment compared with patients treated with other types of treatment.<BR>c) MAD caused the decrease in the urinary excretion of urea in patients suffering from various diseases e.g. malnutrition, muscular atrophies, nephrotic syndrome, addison's disease and ulcerative colitis. Serum level of cholesterol was often found to be decreased in these cases.