諸種薬物投与による糖尿病体の尿中17KS及びその分劃の変動

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The authors observed the changes in the 17 KS content in urine and its fractions following administration of insulin, calcium meso-oxalate (Mesoxan) and sulfonamide derivatives (BZ 55, D 860 and IBTD) to 22 cases and predonisolone, adrenalin. and ACTH to 6 cases of diabetes mellitus hospitalized at this Clinic, for relatively short duration. The results obtained were as follows : <BR>1. Insulin was given to 5 cases in therapeutic doses for 1 to 3 days and 17 KS was found increased in 4 cases and its fractions VI + VII also increased in all the 5 cases. In the case treated further with insulin, the fractions became normalized. <BR>2. Mesoxan was administered to 7 cases for 2 to 6 days in medicament doses. 17 KS was found increased in 5 of them and its fractions VI + VII in 6 cases, showing a tendency similar to that after insulin. <BR>3. Of sulfonamide derivatives, BZ 55 was given to 5 cases, D 860 to 3 cases and IBTD to 2 cases, 10 cases in total. 17 KS was found increased in 4 and decreased in 6 cases, and its fractions VI+VII were found decreased in 8 cases. Thus, in some cases the tendency was opposite to that after insulin. This is perhaps due to the larger length of the observation. <BR>4. In the cases given 20 mg each of predonisolone we could not observe any definite change, but in the cases given 0.5 mg of adrenalin chloride and 25 units of ACTH the 17 KS content and its fractions VI + VII were found increased.
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