正常婦人に於ける尿中Acetaldehydogenic Steroidsに関する研究

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In our experiments with column chromatography to isolate pregnanediol from the toluene extract of β-glucuronidase hydrolysed urine which had been washed by NaOH and taken from normal eighth month pregnant women, we obtained a crystalline substance in the fraction in which pregnanetriol should have been eluted. Investigation of this crystalline substance, revealed that 61.1% of this substance was acetaldehydogenic steroids (AS). Together with this result and with the fact that we had obtained pregnanetriol from the urine of women who were given progesterone, we presumed that urinary AS was mutually related with proesterone metabolism. 1. Two normal women were given 100 mg. of progesterone orally every day during the menstrual cycle, and their urinary AS and 17-OH CS were estimated. AS before administration was found in a slightly greater amount in the progestational phase than in the follicular phase, and was markedly decreased in the ovulatory stadium and just before menstruation. AS markedly increased following administration and a greater amount was found in the cycle after suspension of administration than before administration. The amount of 17-OH CS before administration tended to fluctuate almost parallel with that of AS, decrease following adminstration, and was a little less after suspension than before administration. 2. A normal man and a normal woman were given orally 10 mg. of 17α-ethinyl-5 (10) estraene-19 (β) -0l-3-one (SC-4642 : Searle) every day. The average weekly amounts of AS and 17-OH CS in the male urine before administration were respectively 1.132 mg. a day. In a week of administration his AS markedly decreased and his 17-OH CS tended to decrease a little. In the week following suspension of administration his AS returned to the value administration but the recovery of his 17-OH CS was delayed. As the woman had severe side effects, the administration was ceased after the ninth day. Her AS and 17-OH CS also markedly decreased following administration. After suspension of administration her AS almost recovered but the recovery of her 17-OH CS was delayed. 3. Urinary AS of normal woman was estimated for a period of six days centering around the day when her basal body temperature (B.B.T.) fell. AS was found in the least amount on the day before her B.B.T. fell, but it was markedly raised on the day when her B.B.T. went down. According to the above investigation we found that AS also existed in the urine of normal pregnant women, that the amount of urinary AS of normal non-pregnant women was mutually related with the ovarian cycle, that progesterone tented to hasten the excretion of AS and restained the excretion of 17-OH CS, and that 17α-ethinyl-5 (10) estraene-19 (β) -o1-3-one restained the excretion of both AS and 17-OH CS.
日本内分泌学会の論文

正常婦人に於ける尿中Acetaldehydogenic Steroidsに関する研究

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