高血圧症に於ける血漿及び尿中catecholamineに関する研究
スポンサーリンク
概要
- 論文の詳細を見る
Recently the close relationship of catecholamines to the pathogenesis of hypertension has been brought up to our attention, but very little has been established in regard to the metabolism of catecholamines in human hypertension. <BR>The author estimated the catecholamines in plasma and urine in 250 cases under various conditions with regard to the relationship between blood pressure and these substances. <BR>Weil-Malherbe and Bone's fluorimetric method was employed to estimate plasma catecholamines, while urinary catecholamines were determined by Euler and Floding's method. <BR>Following results were obtained : <BR>1) In 69 healthy subjects and 157 patients with essential hypertension, plasma and urinary levels of noradrenaline (NA) had statistically significant correlation to systolic blood pressure. But no correlation was found between adrenaline (A) and blood pressure. <BR>2) For the same blood pressure levels, plasma NA was higher in aged subjects (over 60 years old) than in adult subjects (below 60 years old). <BR>3) In 18 patients with renal failure, no correlation was found between plasma NA and blood pressure. <BR>4) In 12 healthy subjects and 17 patients with essential hypertension, a good correlation was shown between plasma levels and urinary outputs of NA, but in 11 patients complicated with renal failure the pertinent relationship was not observed. <BR>5) In 2 hypertensive patients both catecholamines and blood pressure were markedly elevated at their usual work. <BR>6) In regard to diurnal variation of catecholamines in plasma and urine, there was no difference between 3 hypertensive patients and 3 healthy subjects, while the day-to-day variation of catecholamines in hypertension was more labile than in healthy subjects. <BR>7) The subcutaneous injection of NA in a dose of 0.5mg caused a definite pressor reaction in 3 hypertensive patients, while no reaction in 3 normotensive subjects and the excretion of NA injected was seemingly retarded in the former. <BR>8) In 15 hypertensive patients plasma levels of NA were considerably decreased after the treatment with hypotensors, and the effects of each hypotensors on plasmacatecholamines suggested the characteristic mechanism of action of these drugs. <BR>These evidences may be suggested that noradrenaline is closely related to the pathogenesis of hypertension.
- 日本内分泌学会の論文