アロキサン犬と除膵犬に於ける副腎cholesterol像に関する実験的研究
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概要
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Torii and Furubayashi of our department reported in 1954 and 1955 respectively that the cholesterol content of adrenal gland particularly of ester cholesterol was found to be markedly reduced in the rats and rabbits injected with alloxan. On the other hand, Long had reported the fact that the cholesterol content of adrenals would be depleted by ACTH in intact animals. <BR>In order to decide whether a large loss of adrenal cholesterol in alloxan animals is due to the effect of extrapancreatic hormones following the injection of alloxan or to the specific effect of diminished function of β cells of pancreas, the author has attempted to study the adrenal cholesterol using the alloxanized dogs and pancreatectomized dogs. The following experimental results were obtained : <BR>1. It was found that in alloxan dogs, the cholesterol content particularly of ester cholesterol of the adrenal tends to show maximum reduction in the initial stage of hyperglycemia and returned to the level of control at the stage of hypoglycemia, but was depleted again at the final hyperglycemic stage. <BR>2. In pancreatectomized dogs, when partial resection of the pancreas was performed (one third of the organ), there occurred no change in the cholesterol picture of adrenals ; however, ester cholesterol had been shown to be definitely reduced both in total and subtotal pancreatectomy. Further experiments have been tried for the comparison. It was shown that with the unilaterally adrenalectomized dogs, the ester cholesterol content of opposite adrenal was increased to the double amounts of normal value, and with the dogs whose stomachs removed three quarter, the increase was moderate. <BR>3. In alloxan dogs, ester cholesterol of liver was reduced during the stage of initial hyperglycemia, the fall was also fonud in the liver of both totally and partially pancreatectomized dogs. However, no change was noted in the dogs, had been removed three fourth of the stomachs as well as in unilaterally adrenalectomized dogs.<BR>4. Pronounced depletion of the ester cholesterol was invariably observed in the adrenals of three different alloxan animals, i.e., rats, rabbits and dogs, but the time for the decrease and the return to the original value were different in respective animals, nevertheless as to the stage of blood sugar for the depletion of adrenal ester cholesterol in the three animals agreed in common at the stage of initial hyperglycemia.<BR>5. In alloxan injected dogs, adrenal ester cholesterol which was markedly depleted during the initial hyperglycemic stage returned to the level of control at the hypoglycemic stage which again showed decrease at the final hyperglycemic stage : on the othr hand, a marked decrease was also observed in both subtotally and totally pancreatectomized dogs. <BR>It seems identical between the final hyperglycemic stage of alloxan dogs and totally pancreatectomized dogs on the pictute of adrenal cholesterol. <BR>From the above findings, it seems logical to assume that for the adrenal cholesterol of alloxan animals at the initial hyperglycemic stage, extrapancreatic hormone did appeared to be involved chiefly, while the function of β cells is likely to be most concerned with the cholesterol change in the final hyper-glycemic stage of alloxan diabetic animals.
- 日本内分泌学会の論文