妊娠時両側卵巣剔除婦人の尿中ホルモン量の消長

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Some urinary hormones, namely 3 fractions of Estrogen (Estrone, Estradiol and Estriol) Pregnanediol, 17-Ketosteroid and Chemocorticoid, were simultaneously meausred after the operation through puerperium of a woman who was given the bilateral oophorectomy of ovarian tumor (Dermoid Cyst) at 7th month pregnancy and progressed favorably after operation, delivering at full term. The results are as followings.<BR>1) Estrogenype, quantity and variation degree of excretion of 3 fractions were same as normal pregnancy and no remarkable change was seen due to oophorectomy.<BR>2) Pregnanedioless pregnanediol was observed during 3 weeks after operation in spite of preoperative injection of Proluton Depot 65mg, which was followed by lapid increase of pregnanediol, indicating least quantity of normal pregnancy through the completion of delivery, then remarkable decrease was again recognized.<BR>3) 17-Ketosteroid, Chemocorticoid-17-KS was slightly increased within 1-3days after operation and chemocorticoid of both free and combined forms also increased. They, however, became normal after this period and gradually went down after delivery as usually seen in normal pregnancy.<BR>Although Waldstein and others have already reported concerning invariable excreation of estrogen due to oophorectomy in pregnancy, this is a primary report which measured 3 fractions of estrogen and other hormones at the same time. The fact that no special difference was found in this case means that placenta is very important as a producing organ of these hormones, while ovary is less valued especially during later half of pregnancy when the placental function has been completed, which shows the complicated mechanism of internal secretion in pregnancy.
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妊娠時両側卵巣剔除婦人の尿中ホルモン量の消長

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