膵尾側切除ノ癲癇患者血液像ニ及ボス影響
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概要
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1). Hemogram of 100 epileptics is almost always normal in the intervals of fits, but slight leucocytosis accompanying eosinophilia has been observed within several hours after grand mal seizures.<BR>2). In 28 out of 33 idiopathic epileptics (84.8%) significant eosinopenia has been observed following caudal resection of the pancreas (3/5 of the entire organ), and persisted over 10 days in 18 cases (54.5%). The persisting postoperative eosinopenia has been more frequently observed in the cases, in which postoperative hyperglycemia was pronouced and longer lasted. The relation between alleviation of epileptic seizures and eosinopenia after the operation was not confirmed. In childhood the persisting postoperative eosinopenia has been rarely observed, but eosinophilia more frequently.<BR>3). Following miscellaneous surgical operations, except caudal resection of the pancreas, significant eosinopenia has been observed in 83.3 per cent of 78 patients with or without epilepsy, but in all cases circulating eosinophils returned to or above preoperative levels within 4 days after operation.<BR>4). Some relation between the number of circulating eosinophils, level of blood sugar, insulin and estrogen after caudal resection of the pancreas was found in epileptics. The persisting depression of circulating eosinophils following caudal resection of the pancreas in epileptics may be caused by an increase in adrenal activity. I suppose that the yet unknown mechanism, which regulates pituitary ACTH secretion, not based on the action of epinephrine, may be concerned with the change in metabolism of zinc following caudal resection of the pancreas.
- 日本内分泌学会の論文