反復刺戟ニヨル卵巣機能ノ變調ニ關スル研究
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概要
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Prof. Y. Tokumitsu and his co-operators have already proved that the repeated injection of the organic cellular component gives rise to the aberration of the same organic function and that the active substance bringing on the abnormal phenomena appears in the blood. Therefore the writer has studied the aberration of the ovarian function by repeated injection of the ovarian-emulsion and has obtained the following results.<BR>1) When 5% ovarian-emulsion is repeatedly injected over 25 times to the mature female rabbit (per 2.0 cc. kg. bodyweight), the injected rabbit becomes negative to the Friedmann test and causes the sterility. And the histological findings of the ovaries show marked hypoplasia of the follicle and early atresia. At this time we have found the active substance in the globulin fraction of the blood-serum which controls the estrus cycle of the mice and brings on the atrophy of the genitals. The ovaries of the mice show the same findings as that of the repeatedly injected rabbit.<BR>2) This active substance in the blood of the injected rabbit disappears by the removal of another endocrine organ. If these removed ovaries are transplanted to another body, the same active substance as before appears in the blood of the tarnsplanted body, so that it is thought that this substance is produced from the ovaries.<BR>3) This substance controls the product and the ability of folliculin, but it has no influence on the male genitals.<BR>From the above experiments, it is evident that the ovarian function alters qualitatively by the repeated irritation of ovarian-emulsion.
- 日本内分泌学会の論文