脾機能ノ變調ニ關スル研究:特ニ脾水浸出液反復注射ニヨル貧血ノ本態ニ就テ

概要

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The pathogenesis of the change of erythrocyte count caused by repeated injection of splenic emulsion is as follows: 1) Spleen produces constantly two kinds of hormone in its venous blood. One of these soluble in ether or alcohol, causes erythropenia and the other, insoluble in them, causes erythrocytosis. 2) When rabbits are injected with a definite amount of splenic emulsion, a slight erythro cytosis occurs, which results from the increase of erythrocytogenous splenic hormone and the decrease of erythropeniogenous one. 3) If this irritation is repeated over 15-20 times with the same quantity, it causes severe anemia on the contray. This anemia results from the increase of erythropeniogenous splenic hormone and the decrease erythrocytogenous one. When the ratio of production of these two active substances are reversed, it can be said to be"aberration of the splenic function." 4) A severe enduring anemia occurs by injecting the emulsion which is made from the above mentioned aberrated spleen, and this anemia is due to the same mechanism as (3). As shown in the above experiments, severe anemia can occur even by repeated injection of the normal splenic emulsion.
一般社団法人日本内分泌学会の論文