Comparison of Analytical Performance of Two Single-Step Measurement Devices of B-Type Natriuretic Peptide
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概要
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Rapid measurement of B-type natriuretic peptide (BNP) plays a practical role in the diagnosis of congestive heart failure. Analytical evaluation of a new small-footprint immunochromatography reader of BNP (Rapidpia<SUP>® </SUP>) was performed and compared with the commercially available SHIONOSPOT<SUP>®</SUP> Reader as the index. The new BNP assay had a within-run coefficient of variation (CV) of 9.0% and a between-run CV of 2.1%. Correlations between whole blood and plasma samples and those with the index SHIONOSPOT<SUP>®</SUP> Reader were y = 0.93x + 0.88, R<SUP>2</SUP> = 0.98 and y = 1.08x - 6.67, R<SUP>2 </SUP>= 0.93, respectively. Based on our findings, the two point-of care (POC) assays for BNP, Rapidpia<SUP>®</SUP> and SHIONOSPOT<SUP>®</SUP> Reader, showed comparable results.